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It is after such evaluation that they can be approved for use in the primary health care.

Such research activities could also lead to the development of new drugs as in the past.

Although Tulsi is known as a general vitalizer and increases physical endurance, it contains no caffeine or other stimulants. may potentially regulate corticosteroid- induced diabetic mellitus. Radio-protective effect Radio-protective effect of aqueous extract of O. (40 mg/kg, for 15 days) in mice exposed to high doses (3.7 MBq) of oral 131 iodine was investigated by studying the organ weights, lipid peroxidation and antioxidant defense enzyme in various target organs like liver, kidney, salivary glands and stomach at 24 h after exposure. In liver, reduced glutathione (GSH) levels showed significant reduction after radiation exposure while pretreatment with O. exhibited less depletion in GSH level even after 131 iodine exposure.

The stem and leaves of holy basil contain a variety of constituents that may have biological activity, including saponins, flavonoids, triterpenoids, and tannins. decreases the serum concentration of both cortisol and glucose and also exhibited antiperoxidative effect. However, no such changes were observed in the stomach. could prevent oxidative damage to liposomal lipids and plasmid DNA induced by various oxidants such as iron, AAPH and gamma radiation. reported that two water-soluble flavonoids, Orientin (Ot) and Vicenin (Vc), isolated from the leaves of O. provide significant protection against radiation, lethality and chromosomal aberration in vivo.

The beneficial medicinal effects of plant materials typically result from the combinations of secondary products present in the plant.

Consequently, the overall effects of Tulsi cannot be fully duplicated with isolated compounds or extracts. This observation indicates the hypoglycemic effect of O. Furthermore, the extract potentiates the action of exogenous insulin in normal rats. at the dose of 50 mg/kg was found to demonstrate maximum cardioprotective effect. have been identified as a protector against Adriamycin (ADR)-induced lipid peroxidation.

Because of its inherent botanical and biochemical complexity, Tulsi standardization has, so far, eluded modern science. significantly decreased renal but not liver weight (expressed as % of body weight) O. The activity of the extract was 91.55 and 70.43% of that of Tolbutamide in normal and diabetic rats, respectively. (50 and 100 mg/kg body weight) daily 30 days inhibit isoproterenol-induced changes in myocardial superoxide dismutase, glutathione peroxidase and reduced glutathione. at the dose of 25, 50, 75 and 100 mg/kg significantly reduced glutathione (GSH), superoxide dismutase and LDH levels. The generation of drug-induced oxygen radicals in heart cells led to cardiac lipid membrane peroxidation. Protection with UA was 13 and 17% in liver and heart microsomes, respectively. was investigated for normal wound healing and dexamethasone-depressed healing.

have been recommended for the treatment of bronchitis, malaria, diarrhea, dysentery, skin disease, arthritis, eye diseases, insect bites and so on. Eugenol (1-hydroxy-2-methoxy-4-allylbenzene), the active constituents present in O. have been found to be largely responsible for the therapeutic potentials.

The pharmacological studies reported in the present review confirm the therapeutic value of O. The results of the above studies support the use of this plant for human and animal disease therapy and reinforce the importance of the ethno-botanical approach as a potential source of bioactive substances.