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Do so only if you are working with a knowledgeable health care professional. Tryptophan: Tryptophan might seem like a logical serotonin supplement to try first since tryptophan is a precursor of serotonin.Together, they can cause too large an increase in serotonin, which can result in a potentially serious condition known as serotonin syndrome. Tryptophan is an amino acid commonly found in protein-rich foods like animal products.But SSRIs can have serious side effects and don’t work for everyone, possibly up to 40 percent of those who try them (1).Some research shows they work no better than a placebo (2).Vitamin B6 (pyridoxine): Vitamin B6 must be present to facilitate conversion of either 5-HTP or tryptophan into serotonin (17, 18).Often 5-HTP or tryptophan supplements also contain B6 for this reason.It’s particularly helpful for Parkinson’s and schizophrenia patients who also have depression (14).

Note that it is not considered safe to mix any of these amino acid supplements with antidepressant medications (4).If this is your situation, here are some serotonin supplements proven to help increase serotonin levels naturally.There are many kinds of nutritional supplements that increase serotonin levels — amino acids, vitamins, minerals, herbs, and more.Several other brain-related disorders besides depression are related to low serotonin, including autism, ADHD, bipolar disorder, sleep disorders, and schizophrenia (3).Many people with depression or other serotonin deficiency symptoms and conditions are searching for better ways to increase serotonin levels naturally without the use of drugs.SAM-e (s-adenosyl methionine): SAM-e naturally occurs in every cell of the body and brain and fuels over 100 metabolic reactions. In Europe, SAM-e is used as a prescription medication for depression, liver disease, and osteoarthritis (11).